Molly Jacob

PROFESSIONAL QUALIFICATIONS

ACADEMIC PROFILE

I have been the head of the Department of Biochemistry, CMC, Vellore, from June 2003 to May 2021. During this time, I have been instrumental in setting up the systems operational in the department for research, teaching and training programs.

Research

I lead the Iron Studies Group (ISG) in the department, which consists of faculty members, PhD and MD trainees, and a post-doctoral fellow. The group is engaged in studying iron homeostasis and its derangements in various medical conditions. These comprise iron-deficiency anemia, iron homeostasis in pregnancy, gestational diabetes mellitus, insulin resistance, and liver disease. All of these constitute medical conditions that are of great public health importance in India. My work is investigator-initiated and hypothesis-driven. The work done involves use of cells in culture, mouse models, and blood and tissue samples from patients with the medical conditions of interest. Another research area I have worked on in the past has been in the study of the pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy and nephropathy.

In the area of iron-deficiency anemia in women, I am engaged in evaluating effectiveness of different dosing regimens for oral iron and how this affects the gut microbiome. I also investigate factors that influence placental iron uptake in pregnancy, and how these determine the iron status of the mother and fetus and outcomes of pregnancy. Other related areas of study include links of iron with gestational diabetes mellitus and pre-term births.

My work on anemia of inflammation (AI) (a challenging condition to treat in clinical practice) has provided important insights into the pathogenesis of the condition, several of which hold implications for effective treatment of AI. In the area of type 2 diabetes mellitus, my group’s work (in wild-type and hepcidin knock-out mice) has shown that iron affects insulin signaling and systemic insulin resistance (IR), and that IR in patients with diabetes mellitus was associated with dysregulated iron homeostasis. My work on chronic liver disease has also provided important insights into its links with iron homeostasis.  

 Undergraduate medical education

I have been involved in teaching programs for undergraduate medical, nursing and para-professional students for over 30 years. My major interest in medical education is to teach Biochemistry effectively to enable students to comprehend the relevance and application of the subject in professional practice in their respective fields. In this regard, I have been responsible for establishing various innovations in the teaching programs in the department. Examples of such innovative initiatives for the undergraduate medical course include regular clinicians’ lectures in the first year of the medical course (based on cases and application of biochemistry in clinical practice), clinical visits for first year medical students, regular case-based small group discussions, development of e-resources for students, integration of teaching of basic and clinical sciences by continuing to teach Biochemistry in the clinical phase of the medical course, conducting workshops on plagiarism, designing assessments based on clinical applications, use of formal feedback from students to improve the course in Biochemistry and sessions to enable students to acquire appropriate attitudes and ethical values required for professionalism.

Postgraduate medical education

In the area of postgraduate teaching and training, my priority has been to develop a program that incorporates training in teaching, diagnostic laboratory work and research, with regular and close supervision of all academic activities involved. Formal training in research methodology and medical education technology are important components of the course. The aim of the program is to equip the trainees with skills in each the above areas. I also supervise MD students working on their dissertations and use every opportunity to instil appropriate attitudes, ethical values and professionalism in postgraduate trainees.

RESEARCH PROJECTS

On-going projects funded by extra-mural grants

1. Iron supplementation during pregnancy and the risk of gestational diabetes mellitus - a randomized, parallel-group, double-blinded clinical trial

Co-investigator

2024 - 2028

Indian Council of Medical Research (ICMR)

2. Effect of iron on pancreatic beta cell function and glucose tolerance in pregnancy 

Co-investigator

2023-2025

Science and Engineering Research Board (SERB) 

3. Is alternate day oral iron more effective in improving iron status of young Indian women than daily doses?

Co-Principal Investigator

2020 -2023

GCRF UCL Internal Small Grants Call of University College, London, UK in partnership with the Overseas Development Agency (ODA), UK

4. Effect of daily supplementation with multiple micronutrients and iron folic acid compared with folic acid alone in children aged 6 to 59 months on anemia prevalence and haemoglobin concentration: a randomized controlled trial in urban Delhi

Co-investigator

2020-2023

Indian Council of Medical Research (ICMR), New Delhi

5. Iron supply in pregnancy

Co-Principal Investigator

2019 to 2023

Deutscher Academischer Austauschdienst (DAAD) German Academic Exchange Service

6. Iron uptake and handling by the placenta – how does this occur and is it affected by inflammation?

Guide and supervisor

2021-2024

Fellowship awarded to Nikhitha Mariya John, under the Young Scientist Scheme (YSS) Department of Health Research (DHR), New Delhi

7. Iron homeostasis in macrophages: is it involved in the development of inflammation in adipose tissue and subsequent insulin resistance?

Guide and supervisor

2021-2024

Fellowship awarded to Dr. Anji Anura (post-doctoral fellow) under the Woman Scientist Scheme (WSS), Department of Health Research (DHR), New Delhi

8. Micronutrient-fortified oil for prevention of anemia, vitamin B12 and folate deficiency in Indian infants

Co-investigator and mentor

2022 to 2023

Collaboration with Dr. Aditi Apte, KEM, Pune, who has been awarded an Early Career Award Program grant funded by the Thrasher Research Foundation, USA.

In addition, I have several on-going research projects funded by intramural funds from CMC’s fluid research grants scheme.

Completed projects

1. Does an iron-overloaded state predispose to an earlier development of insulin resistance in response to a high-fat diet (HFD)?

Principal Investigator

2016 -2020

Science and Engineering Board (SERB), (Department of Science and Technology [DST]), New Delhi

2. Why do patients with Helicobacter pylori infection develop iron-deficiency anemia?

Principal Investigator

2015-2020

Indian Council of Medical Research (ICMR), New Delhi

3. Does the iron content in adipose tissue influence the development of insulin resistance?

Guide and supervisor on senior research fellowship awarded to Jithu V. James

2018 to 2020

Indian Council of Medical Research (ICMR)

4. Why does iron overload associated with insulin resistance occur?

Fellowship Supervisor on an Early Career Fellowship

2012 -2016

Wellcome-Trust DBT India Alliance

5. Iron overload in alcoholic liver disease: why does it occur?

Principal Investigator

2011-2015

Department of Biotechnology (DBT), New Delhi

6. Pharmacogenetics of clozapine response in treatment-resistant schizophrenia

Co-investigator

2011-2014

Department of Biotechnology (DBT), New Delhi

7. How does inflammation affect the handling of iron in the body?

Principal Investigator

2006 -2010

Department of Biotechnology (DBT), New Delhi

8. Pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced renal damage

Principal Investigator

2007-2010

Department of Science and Technology (DST), New Delhi

9. Is activation of haem oxygenase-1 involved in iron accumulation in alcoholic liver disease?

Co-investigator

2008-2011

Department of Biotechnology (DBT), New Delhi

10. Do glutamine and curcumin protect against nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage? If so, how?

Principal Investigator

2004-2007

Council for Scientific and Industrial Research (CSIR), New Delhi

11. Studies on the mechanism of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage

Principal Investigator

2001- 2004

Council for Scientific and Industrial Research (CSIR), New Delhi

RESEARCH COLLABORATIONS

Within CMC, Vellore

Departments of Gastroenterology, Hepatology, Community Medicine, General Surgery and Endocrine Surgery, Obstetrics and the Wellcome Research Unit

Within India

1. Centre for Health Research and Development (CHRD), Society for Applied Studies (SAS), New Delhi

2. Department of Paediatrics, KEM Hospital, Pune

3. Tata Institute of Fundamental Research (TIFR), Mumbai and Hyderabad

4. SIIMA platform- India (Sustainable Scalable Interventions to Improve Maternal and newborn health)

Outside India

1. University of Heidelberg, Germany

2. University College London, UK

3. INSERM, Paris

4. Cincinnati Children's Hospital, USA

PUBLICATIONS

 Research publications:

1. Ramasamy J, Jagadish C, Sukumaran A, Varghese J, Mani T, Joseph AJ, Simon EG, Jacob M. Low Serum Hepcidin Levels in Patients with Ulcerative Colitis - Implications for Treatment of Co-existent Iron-Deficiency Anemia. Inflammation. 2023 Dec;46(6):2209-2222. 

2. James JV, Varghese J, John NM, Deschemin JC, Vaulont S, McKie AT, Jacob M. Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin. J Nutr Biochem. 2023 Jan;111:109175.. 

3. Venkatesan P, Ramasamy J, Vanitha S, Jacob M, Varghese J. Impaired pancreatic beta-cell function after a single dose of oral iron: a before-and-after (pre-post) study. J Hum Nutr Diet. 2022 Aug 24. (IF (2020): 3.089) 

4. Varghese J, Jacob M. Gift authorship: Look the gift horse in the mouth. Indian J Med Ethics. 2022 Apr 21;-(-):1-7. 

5. Venkatesan P, Varghese J, Arthi TS, James JV, Anura A, Prasad J, Jacob M. Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Jun 19:107977. doi: 10.1016/j.jdiacomp.2021.107977. Epub ahead of print. PMID: 34217587. 

6. Ramasamy  J, Job V , Mani  T, Jacob M (2021). Calculated values of serum LDL-cholesterol (LDL-C) – for better or worse? Nutr Metab Cardiovasc Dis 2021 May 6;31(5):1486-1493.doi: 10.1016/j.numecd.2021.01.016. Epub 2021 Jan 29.

7. Varghese J, James JV, Anand R, Narayanasamy M, Rebekah G, Ramakrishna B, Nellickal AJ and Jacob M (2020). Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. Journal of Nutritional Biochemistry https://doi.org/10.1016/j.jnutbio.2020.108441

8. James JV, Varghese J, Mckie AT, Vaulont S, Jacob M. Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118621. doi: 10.1016/j.bbamcr.2019.118621. Epub 2019 Dec 5.

9. Varghese J, James JVJ, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE and Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2019 Nov 28;58:126442. doi: 10.1016/j.jtemb.2019.126442

10. Varghese J, James J, Vaulont S, Mckie A, Jacob M. Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochimica Biophysica Acta (General Subjects) (2018) 1862(9): 1870-1882

11. Rajagopal VM, Rajkumar AP, Jacob KS, Jacob M. Gene-gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia. Pharmacogenet Genomics. 2018 Jan;28(1):31-35

12. Jacob M and Jacob KS. Medicine, medical writing, and India (2016). Indian Journal of Psychiatry 58(3):332-35.

13.  Varghese J, James JV, Sagi S, Chakraborty S, Sukumaran A, Ramakrishna B, Jacob M (2016). Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br J Nutr. 15:1-9. 

14. Nagappan AS, Varghese J, James JV and Jacob M (2015). Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney. Eur J Pharm 15;761:199-205. 

15. Varghese J and Jacob M (2015).  Do medical students require education on issues related to plagiarism? Indian Journal of Medical Ethics Indian J Med Ethics. 2015 Apr-Jun;12(2):82-7.

16.  Rajagopal V, Sundaresan L, Rajkumar AP, Chittybabu C, Kuruvilla A, Srivastava A, Balasubramanian P, Jacob KS, Jacob M (2014). Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea. Psychiatr Genet. 24(6):273-6

17. Nagappan AS, Varghese J, Pranesh GT, Jeyaseelan V, Jacob M (2014). Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage. Chemico-Biological Interactions  Sep 25;221:77-87. 

18. Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ and McKie A (2014). The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematology 164(4):586-96. doi:10.1111/bjh.12649. PMID:24236640

19. Sukumaran A, James J, Janardhan HP, Amaladas A, Suresh LM, Danda D, Jeyeseelan V, Ramakrishna BS and Jacob M (2014). Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders. Br J Nutr 111 (6), 1059–1068.

20. Rajkumar AP, Poonkuzhali B, Kuruvilla A, Jacob M and Jacob KS (2013). Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia. Int Clin Psychopharmacol. 2013 Jan;28(1):50-6. 

21. Rajkumar A, Poonkuzhali, B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2012). Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Psychopharmacology 224 (3): 441-9. 

22. Varghese J, Faith M and Jacob M (2012). Impact of e-resources on learning in biochemistry: first-year medical students’ perceptions. BMC Med Educ. 2012  May 16;12:21. doi: 10.1186/1472-6920-12-21.

23. Sukumaran A, Venkatraman A and Jacob M (2012). Inflammation-induced effects on iron-related proteins in splenic macrophages and the liver in mice. Blood Cells Mol Dis. Jun 15;49(1):11-9. 

24. Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2012). Association between CYP1A2 gene single nucleotide polymorphism and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatrica Article first published online: 6 Mar 2012. DOI: 10.1111/j.1601-5215.2012.00638.x

25.  Sukumaran A, Varghese J, Tamilselvan J, Jeyaseelan V, Mani T, , Simpson RJ, McKie AT and Jacob M (2012). Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. British Journal of Nutrition 108(11):1994-2001.

26. Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada O, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry R, Hughes R, Dhawan A, Patterson C, Simpson RJ and McKie AT (2011). BMPER is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice. Journal of Biological Chemistry 287(6):4099-106.

27. Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2011). Association between CYP1A2 gene single nucleotide polymorphism and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatr. 2013; 25: 2-11.

28.  Sivalingam N, Pichandi S, Chapla A, Dinakaran A and Jacob M (2011).  Zinc protects against indomethacin-induced damage in the rat small intestine. European Journal of Pharmacology: 654(1):106-16

29. Varghese J, Faith M and Jacob M (2010). Impact of electronic resources in teaching biochemistry: a preliminary report. CMC Alumni Journal 44 (1): 62-66. 

30. Sivalingam N, Basivireddy J, Pulimood AB, Balasubramanian KA and Jacob M (2009). Activation of phospholipase A2 is involved in indomethacin-induced damage in Caco-2 cells. Toxicology in Vitro 23(5): 887-96. 

31. Varghese J, Faith M and Jacob M (2009). Zinc ameliorates indomethacin-induced oxidative stress and mitochondrial dysfunction in the rat kidney. European Journal of Pharmacology 614 (1-3): 114-21. 

32. Faith M, Sukumaran A, Pulimood AB and Jacob M (2008). How reliable an indicator of inflammation is myeloperoxidase activity? Clinica Chimica Acta 396 (2008), pp. 23-25. 

33. Sivalingam N, Basivireddy J, Balasubramanian KA and Jacob M (2008). Curcumin protects against indomethacin-induced small intestinal damage by attenuating drug-induced oxidative stress and mitochondrial dysfunction. Archives of Toxicology 82 (7):471-81.

34. Vyas R, Jacob M, Faith M, Isaac B, Rabi S, Sathishkumar S, Selvakumar D and Ganesh A (2008). An effective integrated learning program in the first year of the medical course. The National Medical Journal of India 21 (1): 21-26.

35.  Sivalingam N, Basivireddy J, Balasubramanian KA and Jacob M (2008). Curcumin protects against indomethacin-induced small intestinal damage by attenuating drug-induced oxidative stress and mitochondrial dysfunction. Archives of Toxicology 82 (7):471-81.

36. Jacob M, Foster R, Sigthorsson G, Simpson R and Bjarnason I (2007). Role of bile in pathogenesis of indomethacin-induced enteropathy. Archives of Toxicology 81: 291-8.

37. Sivalingam N, Hanumantharaya R, Faith M, Basivireddy J, Balasubramanian KA and Jacob M (2007). Curcumin reduces indomethacin-induced damage in the rat small intestine. Journal of Applied Toxicology 27 (6): 551-560.

38. Faith M, Eapen CE, Wilfred G, Ramachandran J and Jacob M (2007). Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: a preliminary report. Hepatology Research 37 (1): 13-7.

39. Jacob M, Foster R, Sigthorsson G, Simpson R and Bjarnason I (2007). Role of bile in pathogenesis of indomethacin-induced enteropathy. Archives of Toxicology 81: 291-8.

40. Natarajan SK, Basivireddy J, Ramachandran A, Thomas S, Ramamoorthy P, Pulimood A, Jacob M and Balasubramanian KA (2006). Renal damage in carbon-tetrachloride-induced cirrhosis in rats: role of oxygen free radicals. Hepatology 43: 1248-56.

41. Jacob M and Balasubramaniam N (2006). Excretion of urinary enzymes in normal pregnancy. Clinical Biochemistry 39: 754-757.

42. Basivireddy J, Jacob M, Ramamoorthy P and Balasubramanian KA (2005).  Alterations in the intestinal glycocalyx and bacterial flora in response to oral indomethacin. International Journal of Biochemistry and Cell Biology 37: 2321-2332.

43. Basivireddy J, Jacob M and Balasubramanian KA (2005).  Indomethacin induces free radical-mediated changes in renal brush border membranes. Archives of Toxicology 79: 441-450.

44. Basivireddy J, Jacob M and Balasubramanian KA (2004).  Oral glutamine attenuates indomethacin-induced small intestinal damage. Clinical Science 107: 281-289.

45. Basivireddy J, Jacob M, Pulimood AB and Balasubramanian KA (2004). Indomethacin induced renal damage: role of oxygen free radicals. Biochemical Pharmacology 67: 587-599.

46.  Basivireddy J, Jacob M, Ramamoorthy P, Pulimood AB and Balasubramanian KA (2003). Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. Biochemical Pharmacology 65: 683-95. 

47. Basivireddy J, Vasudevan A, Jacob M and Balasubramanian KA (2002). Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochemical Pharmacology 64: 339-349.

48. Jacob M, Bjarnason I, Simpson RJ (2002). Effects of indomethacin on energy metabolism in jejunal tissue in vivo. Clinical Science 102: 541-546.

49. Jacob M, Bjarnason I, Simpson RJ (2001). Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro. Clinical  Science 101: 493-498.  

50. Jacob M, Bjarnason I, Rafi S, Wrigglesworth J and Simpson RJ (2001). A study of the effects of indomethacin on liver mitochondria from rats, mice and humans. Alimentary Pharmacology and Therapeutics 15: 1837- 1842.

51. Somasundaram S, Sigthorsson G, Simpson RJ, Watts J, Jacob M, et al (2000). Uncoupling of intestinal mitochondria oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Alimentary Pharmacology and Therapeutics 14: 639-650.

52. Jacob M. Mechanism of nonsteroidal drug-induced anti-inflammatory drug-induced damage in the small bowel (1999). PhD thesis submitted to the University of London.

53. Mahmud T, Somasundaram S, Sigthorsson G, Simpson RJ, Rafi S,  Foster R, Tavares IA, Roseth A, Hutt AJ, Jacob M et al (1998). Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat. Gut 43: 775-782.

54. Gabe S, Jacob M and Bjarnason I (1998). The intestinal permeability barrier - what is measured, what does it mean? In: Gut and the Liver. Blum HE, Bode CH, Bode JCH, Sartor RB, eds. FDCH Symposium 100. Kluwer Academic Press, Dordre CHT. 31-46.

55. Mahmud T, Somasundaram S, Sigthorsson G, Simpson RJ, Rafi S,  Foster R, Tavares IA, Roseth A, Hutt AJ, Jacob M et al (1998). Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat. Gut 43: 775-782.

56. Jacob M, Bjarnason I and Simpson RJ (1998). Effects of indomethacin on mitochondrial ATP synthesis. Biochemical Society Transactions 26: S161.

57. Jacob M, Bjarnason I and Simpson RJ (1998). Effects of indomethacin on mitochondrial oxygen uptake in intestine. Biochemical Society Transactions 26: S162.

58. Jacob M, Simpson RJ and Bjarnason I (1998). Non-steroidal anti-inflammatory drugs, cyclooxygenase selectivity and gastrointestinal toxicity. Italian Journal of Gastroenterology and Hepatology 30: 12-18.

59. Jacob M, Bjarnason I and Simpson RJ (1998). In vitro evidence for mitochondrial effects of indomethacin. Biochemical Society Transactions 26: S315.

60. Sigthorsson G, Jacob M, et al (1998). Comparison of indomethacin and nimesulide, a selective cyclooxygenase inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scandinavian Journal of Gastroenterology 33: 728-735.

61. Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M  et al (1997). Intestinal tolerability of the highly specific COX-2 inhibitor, nimesulide, in the rat. Gut 40: (suppl 1) A71.

62. Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M et al (1997). Role of uncoupling of oxidative phosphorylation and inhibition of cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gut 40: (suppl 1) A70.

63. Somasundaram S, Rafi S, Hayllar J,  Jacob M, et al (1997). Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID-induced injury to the rat intestine. Gut 41: 344-353.

64.  Somasundaram S, Rafi S, Jacob M, Sigthorsson G et al (1997). Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Gut 40 (5): 608-613.

65. Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Tavares I, Macpherson A, Bjarnason I (1997) Relative importance of uncoupling of oxidative phosphorylation and inhibition and cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gastroenterology 112 (4S): A290-A290.  

66. Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Mahmud T, Tavares I, Macpherson A, Bjarnason I (1997) Intestinal tolerability of the highly specific-COX-2 inhibitor nimesulide in the rat. Gastroenterology 112 (4S): A291-A291. 

67. Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Tavares I, Macpherson A, Bjarnason I (1997) Role of uncoupling of oxidative phosphorylation and inhibition and cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gut 40: F280-F280.

68. Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Mahmud T, Tavares I, Macpherson A, Bjarnason I (1997) Intestinal tolerability of the highly specific COX-2 inhibitor nimesulide in the rat. Gut 40: F281-F281.

69. Jacob M, Wilfred G, Kanagasabapathy AS and Balasubramaniam N (1995). Urinary calcium-creatinine ratio in the prediction of preeclampsia and pregnancy-induced hypertension. Australian and New Zealand Journal of Obstetrics and Gynecology 35:1: 113.

70. Jacob M, Wilfred G, Kanagasabapathy AS and Balasubramaniam N (1993). Urinary N-acetyl-b-D-glucosaminidase in the prediction of preeclampsia and pregnancy-induced hypertension. Australian and New Zealand Journal of Obstetrics and Gynecology 33:4: 395-397.

Chapters in books:

i. Co-author of Harper’s Illustrated Biochemistry  (32nd edition , 2023) (Kennelly, Botham, McGuiness, Rodwell and Weil). McGraw Hill Lange, USA.

The chapter written is as follows:

Molly Jacob; Joe Varghese; P. Anthony Weil. Chapter 56: Cancer: An Overview

ii. Co-author of Harper’s Illustrated Biochemistry (31st edition , 2018) (Rodwell, Bender, Botham, Kennelly and Weil). McGraw Hill Lange, USA.

The chapters written are as follows:

§   Peter J. Kennelly; Robert K. Murray; Molly Jacob; Joe Varghese. Chapter 52: Plasma Proteins & Immunoglobulins

§   Molly Jacob; Joe Varghese; P. Anthony Weil. Chapter 56: Cancer: An Overview

iii. Co-author of Harper’s Illustrated Biochemistry (3(0th edition, 2015) (Rodwell, Bender, Botham, Kennelly and Weil). McGraw Hill Lange, USA.

The chapters written are as follows:

§   David A. Bender, Joe Varghese, Molly Jacob and Robert K. Murray. Chapter 48. Clinical Biochemistry

§   Peter J. Kennelly, Robert K. Murray, Molly Jacob and Joe Varghese. Chapter 52. Plasma Proteins & Immunoglobulins

§   Molly Jacob, Joe Varghese, Robert K. Murray and P. Anthony Weil. Chapter 56. Cancer: An Overview

iv. Co-author of Harper’s Illustrated Biochemistry (29th edition, 2012) McGraw-Hill Publishers (Lange)

The chapters written are as follows:

§   Robert K. Murray, Molly Jacob and Joe Varghese. Chapter 50. Plasma Proteins & Immunoglobulins

§   Robert K. Murray, Molly Jacob and Joe Varghese. Chapter 55. Cancer: An Overview

§   Joe Varghese, Molly Jacob and Robert K. Murray. Chapter 56. Clinical Biochemistry

PROFESSIONAL MEMBERSHIPS

1. Fellow of the Royal College of Pathologists, UK

2. Fellow of the National Academy of Sciences of India

3. Association of Medical Biochemists of India (AMBI)

4. International Bio-Iron Society (IBIS)

AWARDS

1. The Fr Lourdu Yedanapalli Medal for Research from Christian Medical College, Vellore, India in 2007, for significant contribution by a young researcher in the institution.

2. ICMR Kshanika Oration Award from the Indian Council of Medical Research, New Delhi, India, in 2009, for significant contributions in biomedical research in India.

3. Chintala Sita Devi Oration Award from the Association of Medical Biochemists of India in Dec 2012.

4. Jacob Chandy Research Chair, Christian Medical College, Vellore (2013 to 2016)

5. AS Saini Oration Award at the 23rd Annual Conference of the Association of Medical Biochemists of India in Nov 2014

6. Senior Scientist Award at the 2nd International Workshop on Micronutrients and Child Health, held at the All-India Institute of Medical Sciences, New Delhi from Nov 2014.

7. Fellowship of the National Academy of Sciences of India, 2015

8. Jacob Chandy Research Chair, Christian Medical College, Vellore, India (2018- 2021)

9. Fellowship of the Royal College of Pathologists (UK), in 2019 (based on publications)

10. Jacob Chandy Research Chair, Christian Medical College, Vellore, India (2022- 2026)

MISCELLANEOUS OTHER ACADEMIC ROLES

Within CMC, Vellore

1. Member of Institutional Bio-Safety Committee (IBSC)

2. Resource person for Good Clinical Practice (GCP) workshops conducted by CMC

3. Resource person for foundation courses for 1st year and 1st clinical year MBBS students

4. Resource person for AETCOM sessions for 1st year MBBS students

5. Chairperson of the Institutional Animal Care and Utilization Committee (IACUC) of the Centre for Stem Cell Research (CSCR), CMC

Outside of CMC

1. Indian Council of Medical Research (ICMR), New Delhi

Member of task forces on anemia and non-alcoholic fatty liver disease (NAFLD) of the Indian Council of Medical Research (ICMR) and of several of its project review committees

2. Department of Biotechnology (DBT), New Delhi

Member of the Task Force for Public Health and Nutrition of the Department of Biotechnology (DBT), New Delhi