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PUBLICATIONS RELATED TO IRON METABOLISM

1. James JV, Varghese J*, John NM, Deschemin JC, Vaulont S, McKie AT, Jacob M. Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin: Hepcidin modulates insulin resistance. J Nutr Biochem. 2022 Oct 9:109175. (IF-2021 – 6.117) * - co-first author

2. Venkatesan P, Ramasamy J, Vanitha S, Jacob M, Varghese J. Impaired pancreatic beta-cell function after a single dose of oral iron: a before-and-after (pre-post) study. J Hum Nutr Diet. 2022 Aug 24. (IF-2020 - 3.089) 

3. Venkatesan P, Varghese J*, Arthi TS, James JV, Anura A, Prasad J, Jacob M. Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Jun 19:107977. doi: 10.1016/j.jdiacomp.2021.107977. (IF: 2.852) * co-first author

4. Varghese J, James JV, Narayanasamy M, Anand R, Rebekah G, Ramakrishna B, Nellickal AJ, and Jacob M. Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. J. Nutr. Biochem (May 2020). 84:108441 (IF: 4.490)

5. James JV, Varghese J*, Mckie AT, Vaulont S, Jacob M. Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice. Biochim Biophys Acta Mol Cell Res. 2019 Dec 5;:118621. (IF: 4.739) *co-first author

6. Varghese J, James JV, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2019 Nov 28;58:126442. (IF: 3.755)

7. Varghese J, James J, Vaulont S, Mckie A, Jacob M (2018). Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1870-1882. (IF: 4.007)

8. Varghese J, James JV, Sagi S, Sukumaran A, Ramakrishna B and Jacob M (2016). Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br. J Nutr 2016 Jun;115(11):1978-86 (IF: 3.657)

9. Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ, McKie AT. The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematol. 2014 Feb;164(4):586-96. (IF: 5.128)

10. Sukumaran A, Varghese J, Tamilselvan J, Jeyaseelan V, Mani T, Simpson RJ, McKie AT, Jacob M Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. Br. J Nutr. 2012 Feb 24:1-8 (IF: 3.657)

11. Sukumaran A, James J, Janardhan HP, Amaladas A, Suresh LM, Danda D, Jeyeseelan V, Ramakrishna BS and Jacob M (2014). Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders. Br J Nutr 111 (6), 1059–1068. Impact factor of journal: 3.3

12. Sukumaran A, Venkatraman A and Jacob M (2012). Inflammation-induced effects on iron-related proteins in splenic macrophages and the liver in mice. Blood Cells Mol Dis. 2012 Apr 13. 

13. Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada O, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry R, Hughes R, Dhawan A, Patterson C, Simpson RJ and McKie AT (2012). BMPER is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice. J Biol Chem 287(6): 4099-106.

PUBLICATIONS RELATED TO OTHER AREAS OF INTEREST

Medical Education

1. Varghese J and Jacob M (2015). Do medical students require education on issues related to plagiarism? Indian Journal of Medical Ethics Indian J Med Ethics. 2015 Apr-Jun;12(2):82-7.

2. Varghese J, Faith M and Jacob M (2012). Impact of e-resources on learning in biochemistry: first-year medical students’ perceptions. BMC Med Educ. 2012 Apr 17;12(1):21. 

3. Varghese J, Faith M and Jacob M (2010). Impact of electronic resources in teaching biochemistry: a preliminary report. CMC Alumni Journal 44 (1): 62-66.

4. Vyas R, Jacob M, Faith M, Isaac B, Rabi S, Sathishkumar S, Selvakumar D and Ganesh A (2008). An effective integrated learning program in the first year of the medical course. The National Medical Journal of India 21 (1): 21-26.

Non-steroidal anti-inflammatory drugs (NSAIDs)

1. Nagappan AS, Varghese J, James JV and Jacob M (2015). Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney. Eur J Pharm 15;761:199-205. Impact factor of journal: 2.73

2. Nagappan AS, Varghese J, Pranesh GT, Jeyaseelan V, Jacob M (2014). Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage. Chemico-Biological Interactions Sep 25;221:77-87. Impact factor of journal: 2.577

3. Sivalingam N, Pichandi S, Chapla A, Dinakaran A and Jacob M (2011). Zinc protects against indomethacin-induced damage in the rat small intestine. European Journal of Pharmacology 654(1): 106-16. 

4. Sivalingam N, Basivireddy J, Pulimood AB, Balasubramanian KA and Jacob M (2009). Activation of phospholipase A2 is involved in indomethacin-induced damage in Caco-2 cells. Toxicology in Vitro 23(5): 887-96.

5. Varghese J, Faith M and Jacob M (2009). Zinc ameliorates indomethacin-induced oxidative stress and mitochondrial dysfunction in the rat kidney. European Journal of Pharmacology 614 (1-3): 114-21.

6. Sivalingam N, Basivireddy J, Balasubramanian KA and Jacob M (2008). Curcumin protects against indomethacin-induced small intestinal damage by attenuating drug-induced oxidative stress and mitochondrial dysfunction. Archives of Toxicology 82 (7):471-81.

7. Sivalingam N, Hanumantharaya R, Faith M, Basivireddy J, Balasubramanian KA and Jacob M (2007). Curcumin reduces indomethacin-induced damage in the rat small intestine. Journal of Applied Toxicology 27 (6): 551-560.

8. Jacob M, Foster R, Sigthorsson G, Simpson R and Bjarnason I (2007). Role of bile in pathogenesis of indomethacin-induced enteropathy. Archives of Toxicology 81: 291-8.

9. Basivireddy J, Jacob M, Ramamoorthy P and Balasubramanian KA (2005). Alterations in the intestinal glycocalyx and bacterial flora in response to oral indomethacin. International Journal of Biochemistry and Cell Biology 37: 2321-2332.

10. Basivireddy J, Jacob M and Balasubramanian KA (2005). Indomethacin induces free radical-mediated changes in renal brush border membranes. Archives of Toxicology 79: 441-450.

11. Basivireddy J, Jacob M and Balasubramanian KA (2004). Oral glutamine attenuates indomethacin-induced small intestinal damage. Clinical Science 107: 281-289.

12. Basivireddy J, Jacob M, Pulimood AB and Balasubramanian KA (2004). Indomethacin induced renal damage: role of oxygen free radicals. Biochemical Pharmacology 67: 587-599.

13. Basivireddy J, Jacob M, Ramamoorthy P, Pulimood AB and Balasubramanian KA (2003). Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. Biochemical Pharmacology 65: 683-95.

14. Basivireddy J, Vasudevan A, Jacob M and Balasubramanian KA (2002). Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochemical Pharmacology 64: 339-349.

15. Jacob M, Bjarnason I, Simpson RJ (2002). Effects of indomethacin on energy metabolism in jejunal tissue in vivo. Clinical Science 102: 541-546.

16. Jacob M, Bjarnason I, Simpson RJ (2001). Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro. Clinical Science 101: 493-498.

17. Jacob M, Bjarnason I, Rafi S, Wrigglesworth J and Simpson RJ (2001). A study of the effects of indomethacin on liver mitochondria from rats, mice and humans. Alimentary Pharmacology and Therapeutics 15: 1837- 1842.

18. Jacob M. Mechanism of nonsteroidal drug-induced anti-inflammatory drug-induced damage in the small bowel (1999). PhD thesis (University of London).

19. Mahmud T, Somasundaram S, Sigthorsson G, Simpson RJ, Rafi S, Foster R, Tavares IA, Roseth A, Hutt AJ, Jacob M et al (1998). Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat. Gut 43: 775-782.

20. Jacob M, Bjarnason I and Simpson RJ (1998). Effects of indomethacin on mitochondrial ATP synthesis. Biochemical Society Transactions 26: S161.

21. Jacob M, Bjarnason I and Simpson RJ (1998). Effects of indomethacin on mitochondrial oxygen uptake in intestine. Biochemical Society Transactions 26: S162.

22. Jacob M, Simpson RJ and Bjarnason I (1998). Non-steroidal anti-inflammatory drugs, cyclooxygenase selectivity and gastrointestinal toxicity. Italian Journal of Gastroenterology and Hepatology 30: 12-18.

23. Jacob M, Bjarnason I and Simpson RJ (1998). In vitro evidence for mitochondrial effects of indomethacin. Biochemical Society Transactions 26: S315.

24. Sigthorsson G, Jacob M, et al (1998). Comparison of indomethacin and nimesulide, a selective cyclooxygenase inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scandinavian Journal of Gastroenterology 33: 728-735.

25. Gabe S, Jacob M and Bjarnason I (1998). The intestinal permeability barrier - what is measured, what does it mean? In: Gut and the Liver. Blum HE, Bode CH, Bode JCH, Sartor RB, eds. FDCH Symposium 100. Kluwer Academic Press, Dordre CHT. 31-46.

26. Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M et al (1997). Intestinal tolerability of the highly specific COX-2 inhibitor, nimesulide, in the rat. Gut 40: (suppl 1) A71.

27. Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M et al (1997). Role of uncoupling of oxidative phosphorylation and inhibition of cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gut 40: (suppl 1) A70.

28. Somasundaram S, Rafi S, Hayllar J, Jacob M, et al (1997). Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID-induced injury to the rat intestine. Gut 41: 344-353.

29. Somasundaram S, Rafi S, Jacob M, Sigthorsson G et al (1997). Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Gut 40 (5): 608-613.

30. Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Tavares I, Macpherson A, Bjarnason I (1997). Relative importance of uncoupling of oxidative phosphorylation and inhibition and cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gastroenterology 112 (4S): A290-A290.

31. Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Mahmud T, Tavares I, Macpherson A, Bjarnason I (1997) Intestinal tolerability of the highly specific-COX-2 inhibitor nimesulide in the rat. Gastroenterology 112 (4S): A291-A291.

32. Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Tavares I, Macpherson A, Bjarnason I (1997) Role of uncoupling of oxidative phosphorylation and inhibition and cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gut 40: F280-F280.

33. Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Mahmud T, Tavares I, Macpherson A, Bjarnason I (1997) Intestinal tolerability of the highly specific COX-2 inhibitor nimesulide in the rat. Gut 40: F281-F281.

Others

1. Rajagopal V, Sundaresan L, Rajkumar AP, Chittybabu C, Kuruvilla A, Srivastava A, Balasubramanian P, Jacob KS, Jacob M (2014). Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea. Psychiatr Genet. 24(6):273-6. Impact factor of journal: 2.3

2. Rajkumar AP, Poonkuzhali B, Kuruvilla A, Jacob M and Jacob KS (2013). Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia. International Clinical Psychopharmacology 28(1):50-6.

3. Rajkumar A, Poonkuzhali, B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2012). Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Psychopharmacology 224 (3): 441-9.

4. Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2012). Association between CYP1A2 gene single nucleotide polymorphism and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatrica (published online: 6 Mar 2012. DOI: 10.1111/j.1601 5215.2012.00638.x

5. Faith M, Sukumaran A, Pulimood AB and Jacob M (2008). How reliable an indicator of inflammation is myeloperoxidase activity? Clinica Chimica Acta 396: 23-25.

6. Faith M, Eapen CE, Wilfred G, Ramachandran J and Jacob M (2007). Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: a preliminary report. Hepatology Research 37 (1): 13-7.

7. Natarajan SK, Basivireddy J, Ramachandran A, Thomas S, Ramamoorthy P, Pulimood A, Jacob M and Balasubramanian KA (2006). Renal damage in carbon-tetrachloride-induced cirrhosis in rats: role of oxygen free radicals. Hepatology 43: 1248-56.

8. Jacob M and Balasubramaniam N (2006). Excretion of urinary enzymes in normal pregnancy. Clinical Biochemistry 39: 754-757.

9. Jacob M, Wilfred G, Kanagasabapathy AS and Balasubramaniam N (1995). Urinary calcium-creatinine ratio in the prediction of preeclampsia and pregnancy-induced hypertension. Australian and New Zealand Journal of Obstetrics and Gynecology 35: 113. 

10. Jacob M, Wilfred G, Kanagasabapathy AS and Balasubramaniam N (1993). Urinary N-acetyl-b-D-glucosaminidase in the prediction of preeclampsia and pregnancy-induced hypertension. Australian and New Zealand Journal of Obstetrics and Gynecology 33: 395-397.