(The names in bold indicate authors from the Department of Biochemistry)
James JV, Varghese J*, John NM, Deschemin JC, Vaulont S, McKie AT, Jacob M. Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin. J Nutr Biochem. 2023 Jan;111:109175. doi: 10.1016/j.jnutbio.2022.109175. Epub 2022 Oct 9. PMID: 36223834. (IF-2021 – 6.117) * - co-first author
Venkatesan P, Varghese J*, Arthi TS, James JV, Anura A, Prasad J, Jacob M. Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Jun 19:107977. doi: 10.1016/j.jdiacomp.2021.107977. (IF: 2.852) *co-first author
Ramasamy J, Job V, Mani T, Jacob M. Calculated values of serum LDL-cholesterol (LDL-C) - for better or worse? Nutrition Metabolism Cardiovascular Disease. 2021 Jan 21, doi: 10.1016/j.numecd.2021.01.016. PMID: 33744036. (Impact factor 4.22)
Ramamoorthy H, Abraham P, Isaac B. Melatonin protects against tenofovir-induced nephrotoxicity in rats by targeting multiple cellular pathways. Human and experimental toxicology 2021 May;40(5):826-850
Varghese J, James JV, Anand R, Narayanasamy M, Rebekah G, Ramakrishna B, Nellickal AJ, Jacob M Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. J Nutr Biochem (2020), 84: 108441 (IF: 4.51)
James JV, Varghese J, Mckie AT, Vaulont S, Jacob M. Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice. Biochim Biophys Acta Mol Cell Res. 2019 Dec 5;:118621. (IF: 4.739)
Varghese J, James JV, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2019 Nov 28;58:126442. (IF: 2.895)
Anand R, and Prakash SS (2019). Factors influencing the career preferences of medical students and interns: a cross-sectional, questionnaire-based survey from India. Journal of Educational Evaluation for Health Professions. 2019;16:12. Epub 2019 May 15.
Muthuraman N, Anand R, and Prakash SS (2019). Factors influencing to study medicine: a survey of first-year medical students from India. Korean Journal of Medical Education. 31:61-71.
Rammamoorthy H, Abraham P. Mitochondrial pathway of apoptosis and necrosis contribute to tenofovir disoproxil fumarate -induced renal damage in rats. Human and experimental toxicology . 2019 Mar;38(3):288-30.
Varghese J, James JV, Vaulont S, Mckie A and Jacob M (2018). Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta. 2018 May 31;1862(9):1870-1882. (IF: 3.681)
Natarajan K, Abraham P, Kota R, Isaac B. NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats. Food Chem Toxicol. 2018 ;118:766-783
Anand Ruban, Prakash Somi Sankaran. A proposal based on a review of reforms for improving medical education in India (Letter). Postgrad Med J. 2017 Oct 24. pii: postgradmedj-2017-135328.
Prakash SS, Muthuraman N, Anand R. Short-duration podcasts as a supplementary learning tool: perceptions of medical students and impact on assessment performance. BMC Med Educ. 2017 Sep 18;17(1):167.
Prakash SS, Soundrarajan J. Advising residents on how to present an article in a journal club. Postgrad Med J. 2017 Jun;93(1100) 364-365.
Ramamoorthy H, Abraham P, Isaac B, Selvakumar D. Role for NF-κB inflammatory signalling pathway in tenofovir disoproxil fumarate (TDF) induced renal damage in rats. Food Chem Toxicol 2017 Jan; 99:103-118.
Natarajan K, Abraham P, Kota R, Selvakumar D. Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes J Basic Clin Physiol Pharmacol. 2017 ;28 (3):239-247.
Abraham P, Hemalatha R, Francis DV, Suganthy R. Beneficial Effects of Megadoses of Biotin in Streptozotocin-induced Gestational Diabetes Mellitus in Rats – A Preliminary Study. Indian J Physiol Pharmacol 2017; 61(2) :159-165
Prakash SS. What is the relevance of MBBS course in the era of specializations? International Journal of Scientific Research Vol. 5 Issue 8, Pg 543-44 August 2016.
Wani WY, Kandimalla RJ, Sharma DR, Kaushal A, Ruban A, Sunkaria A, Vallamkondu J, Chiarugi A, Reddy PH, Gill KD. Cell cycle activation in p21 dependent pathway: An alternative mechanism of organophosphate induced dopaminergic neurodegeneration. Biochim Biophys Acta. 2016 Jun 2. pii: S0925-4439(16)30130-2.
Pananghat AN, Aggarwal H, Prakash SS, Makhdoomi MA, Singh R, Lodha R, Ali S, Srinivas M, Das BK, Pandey RM, Kabra SK, Luthra K. IL-8 alterations in HIV-1 infected children with disease progression. Medicine (Baltimore). 2016 May;95(21):e3734.
Varghese J, James JV, Sagi S, Chakraborty S, Sukumaran A, Ramakrishna B, Jacob M (2016). Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br J Nutr. 2016 Apr 15:1-9. [Epub ahead of print]. Impact factor of journal: 3.3
Abraham P, Rabi S, Francis DV, D Mohana Priya, Natarajan K, A. Amaladass (2016). Increased hepatic gluconeogenesis and decreased glucose uptake, and increased hepatic de novo lipogenesis in rat model of maternal diabetes. Biomedical Research 2016; 27 (2): 621-629. Impact factor of journal: 0.236
Natarajan K, Abraham P, Isaac B (2016). Effect of methotrexate treatment on iNOS gene expression, protein tyrosine nitration protein cysteine nitrosylation, and the activities of mitochondrial enzymes in the small intestinal mucosa of rats. Asian Journal of Pharmacology and Toxicology (in press).
Natarajan K, Abraham P (2016). Methotrexate administration induces differential and selective protein tyrosine nitration and cysteine nitrosylation in the subcellular organelles of the small intestinal mucosa of rats. Chem Biol Interact. 2016 May 5;251:45-59. Impact factor of journal: 2.577
Rashmi Vyas, Minnie Faith, Dhayakani Selvakumar, Anna Pulimood and Mary Lee. Project-based faculty development for e-learning. Clinical Teacher. Article first published online: 18 JAN 2016 | DOI: 10.1111/tct.12486.
Nagappan AS, Varghese J, James JV and Jacob M (2015). Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney. Eur J Pharm 15;761:199-205. Impact factor of journal: 2.73
Varghese J and Jacob M (2015). Do medical students require education on issues related to plagiarism? Indian J Med Ethics. 2015 Apr-Jun;12(2):82-7.
Abraham P, Hemalatha R, Isaac B. A reliable and reproducible rodent model of Tenofovir disoproxil fumarate (TDF) (anti-HIV drug) nephrotoxicity that resembles human TDF tubulopathy. Biomedical research 2015 : 27 (1): 974-982. Impact factor of journal: 0.236
Bure D, Makhdoomi MA, Lodha R, Prakash SS, Kumar R, Parray HA, Singh R, Kabra SK, Luthra K. Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naïve and treated pediatric patients. Viruses. 2015 Feb 10;7(2):590-603. Impact factor of journal: 3.2
Rajagopal V, Sundaresan L, Rajkumar AP, Chittybabu C, Kuruvilla A, Srivastava A, Balasubramanian P, Jacob KS, Jacob M (2014). Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea. Psychiatr Genet. 24(6):273-6. Impact factor of journal: 2.3
Nagappan AS, Varghese J, Pranesh GT, Jeyaseelan V, Jacob M (2014). Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage. Chemico-Biological Interactions Sep 25;221:77-87. Impact factor of journal: 2.577
Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ and McKie A (2014). The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematology 164(4):586-96. Impact factor of journal: 4.94
Sukumaran A, James J, Janardhan HP, Amaladas A, Suresh LM, Danda D, Jeyeseelan V, Ramakrishna BS and Jacob M (2014). Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders. Br J Nutr 111 (6), 1059–1068. Impact factor of journal: 3.3
Anand R, Prakash SS, Veeramanikandan R, Richard Kirubakaran. Association between Apolipoprotein E genotype and cancer susceptibility: a meta-analysis. Journal of Cancer Research and Clinical Oncology 2014 140(7):1075-85. Impact factor of journal: 3.0
Kandimalla RJ, Anand R, Veeramanikandan R, Wani WY, Prabhakar S, Grover VK, et al. CSF Ubiquitin as a Specific Biomarker in Alzheimer's Disease. Current Alzheimer research. 2014. 11(4):340-8.
Gautham T Pranesh and Minnie Faith. An assessment of standardization of HbA1c testing across clinical laboratories in India & its impact on diabetes management. Journal of the Association of the Physicians of India. January 2014, Vol 62 p 18-22.
Ramamoorthy H, Abraham P, Isaac B (2014). Mitochondrial Dysfunction and Electron Transport Chain Complex Defect in a Rat Model of Tenofovir Disoproxil Fumarate Nephrotoxicity. J Biochem Mol Toxicol. 2014 Jun;28(6):246-55. Impact factor of journal: 1.59
Kolli VK, Natarajan K, Isaac B, Selvakumar D, Abraham P (2014). Mitochondrial dysfunction and respiratory chain defects in a rat model of methotrexate-induced enteritis. Hum Exp Toxicol. 2014 Oct;33(10):1051-65. Impact factor of journal: 1.40
Anand R, Kiran Dip Gill, Abbas Ali Mahdi. Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology. 2014 Jan, 76 PtA:27-50. Impact factor: 4.39
Rajkumar AP, Poonkuzhali B, Kuruvilla A, Jacob M and Jacob KS (2013). Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia. International Clinical Psychopharmacology 28(1):50-6.
Faith M and Abraham P. An update on diagnostic value of biotinidase: From liver damage to cancer: Minireview Biomedical Research 2013; 24 (2): 195-201. Impact factor of journal: 0.236
Abraham P, Ramamoorthy H, Isaac B. Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate - induced mitochondrial damage and increased oxido-nitrosative stress in the kidney. J Biomed Sci. 2013 Aug 19;20:61. doi: 10.1186/1423-0127-20-61.
Kolli VK, Kanakasabapathy I, Faith M, Ramamoorthy H, Isaac B, Natarajan K, Abraham P. A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation. Cancer Chemother Pharmacol. 2013 May;71(5):1209-18.
Anand R, Deepraj Sharma, Deepika Verma, Kiran Dip Gill, Ashish Bhalla, Surjit Singh. Mitochondrial electron transport chain complexes, catalase and markers of oxidative stress in platelets in patients with severe aluminum phosphide poisoning. Human and Experimental Toxicology 2013 Aug;32(8):807-16. Impact factor: 1.45
Alka Kaushal, Willayat Yousuf Wani, Anand R, Kiran Dip Gill. Spontaneous and Induced non transgenic models of AD: Hypoxia and Okadaic acid- a combinatorial approach. American Journal of Alzheimer's disease and other dementias. 2013 Jun;28(4):318-26. Impact factor: 1.52
Ramesh JL Kandimalla, Willayat Yousuf Wani, Anand R, Alka Kaushal, Kiran Dip Gill. Apolipoprotein E levels in the cerebrospinal fluid of North Indian Alzheimer’s disease patients. American Journal of Alzheimer's disease and other dementias. 2013 May; 28(3): 258-262. Impact factor: 1.52
Rajkumar A, Poonkuzhali, B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2012). Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Psychopharmacology 224 (3): 441-9.
Kolli VK, Abraham P, Isaac B, Kasthuri N (2012). Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats. Dig Dis Sci (in press).
Varghese J, Faith M and Jacob M (2012). Impact of e-resources on learning in biochemistry: first-year medical students’ perceptions. BMC Med Educ. 2012 Apr 17;12(1):21. [Epub ahead of print]
Sukumaran A, Venkatraman A and Jacob M (2012). Inflammation-induced effects on iron-related proteins in splenic macrophages and the liver in mice. Blood Cells Mol Dis. 2012 Apr 13. [Epub ahead of print]
Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M and Jacob KS (2012). Association between CYP1A2 gene single nucleotide polymorphism and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatrica (published online: 6 Mar 2012. DOI: 10.1111/j.1601 5215.2012.00638.x
Sukumaran A, Varghese J, Tamilselvan J, Jeyaseelan V, Mani T, , Simpson RJ, McKie AT and Jacob M (2012). Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. British Journal of Nutrition 108(11):1994-2001.
Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada O, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry R, Hughes R, Dhawan A, Patterson C, Simpson RJ and McKie AT (2012). BMPER is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice. Journal of Biological Chemistry 287(6): 4099-106.
Abraham P, Isaac B (2011). The effects of oral glutamine on cyclophosphamide-induced nephrotoxicity in rats. Human and Experimental Toxicology 30: 616-23.
Abraham P, Isaac B, Ramamoorthy H, Natarajan K (2011). Oral glutamine attenuates cyclophosphamide-induced oxidative stress in the bladder but does not prevent hemorrhagic cystitis in rats. Journal of Medical Toxicology 7: 118-24.
Abraham P, Isaac B (2011). Ultrastructural changes in the rat kidney after single dose of cyclophosphamide-possible roles for peroxisome proliferation and lysosomal dysfunction in cyclophosphamide induced renal damage. Human and Experimental Toxicology 30: 1924-30.
Abraham P, Rabi S (2011). Protective effect of aminoguanidine against cyclophosphamide induced oxidative stress and renal damage in rats. Redox Report 16: 6-12.
Abraham P, Rabi S (2011). Aminoguanidine, a selective nitric oxide synthase inhibitor, attenuates cyclophosphamide-induced renal damage by inhibiting protein nitration and PARP(S) activation. Chemotherapy 57: 327-334.
Ramamoorthy H, Abraham P, Isaac B (2011). Oxidative stress, decreased activities of anti-oxidant enzymes, and neutrophil infiltration contribute toTenofovirdisoproxilfumarate induced renal damagein rats. International Research of Pharmacy and Pharmacology 1(10): 259-270.
Sivalingam N, Pichandi S, Chapla A, Dinakaran A and Jacob M (2011). Zinc protects against indomethacin-induced damage in the rat small intestine. European Journal of Pharmacology 654(1): 106-16.
Abraham P, Kolli VK, Rabi S (2010). Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats. Cell Biochemistry and Functions 28:426-33.
Varghese J, Faith M and Jacob M (2010). Impact of electronic resources in teaching biochemistry: a preliminary report. CMC Alumni Journal 44 (1): 62-66.
Abraham P, Rabi S, Selvakumar D (2009). Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat. Cell Biochemistry and Functions 27: 56-62.
Abraham P, Rabi S, Kulothungan P (2009). Aminoguanidine, selective nitric oxide synthase inhibitor, ameliorates cyclophosphamide-induced hemorrhagic cystitis by inhibiting protein nitration and PARS activation. Urology 73:1402-6.
Abraham P, Rabi S (2009). Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat. Cancer Chemotherapy and Pharmacology 64: 279-84.
Abraham P, Suganthy R (2009). Nitrosative stress, protein tyrosine nitration, PARP activation and NAD depletion in the kidneys of rats after single dose of cyclophosphamide. Clinical and Experimental Nephrology 13:281-7.
Abraham P, Kolli VK, Isaac B, Selvakumar D (2009). Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage. Chemotherapy 55: 83-90.
Sivalingam N, Basivireddy J, Pulimood AB, Balasubramanian KA and Jacob M (2009). Activation of phospholipase A2 is involved in indomethacin-induced damage in Caco-2 cells. Toxicology in Vitro 23(5): 887-96.
Varghese J, Faith M and Jacob M (2009). Zinc ameliorates indomethacin-induced oxidative stress and mitochondrial dysfunction in the rat kidney. European Journal of Pharmacology 614 (1-3): 114-21.
Kolli VK, Abraham P, Rabi S (2008). Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat. Archives of Toxicology 82:763-70.
Abraham P, Sugumar E (2008). Increased glutathione levels and activity of PON1 (phenyl acetate esterase) in the liver of rats after a single dose of cyclophosphamide: a defense mechanism? Experimental and Toxicologic Pathology 59:301-6.
Abraham P, Sugumar E (2008). Enhanced PON1 activity in the kidneys of cyclophosphamide treated rats may play a protective role as an antioxidant against cyclophosphamide induced oxidative stress. Archives of Toxicology 82:237-8.
Abraham P, Kanakasabapathy I, Kulothungan P (2008). Alterations in antioxidant enzyme activities and increased oxidative stress in cyclophosphamide induced hemorrhagic cystitis in the rat. Cancer Therapy 6: 563-570.
Faith M, Sukumaran A, Pulimood AB and Jacob M (2008). How reliable an indicator of inflammation is myeloperoxidase activity? Clinica Chimica Acta 396: 23-25.
Vyas R, Jacob M, Faith M, Isaac B, Rabi S, Sathishkumar S, Selvakumar D and Ganesh A (2008). An effective integrated learning program in the first year of the medical course. The National Medical Journal of India 21 (1): 21-26.
Sivalingam N, Basivireddy J, Balasubramanian KA and Jacob M (2008). Curcumin protects against indomethacin-induced small intestinal damage by attenuating drug-induced oxidative stress and mitochondrial dysfunction. Archives of Toxicology 82 (7):471-81.
Sugumar E, Indirani K, Abraham P (2007). Normal plasma creatinine levels despite histological evidence of renal damage in cyclophosphamide-treated rats. Clinica Chimica Acta 376: 244-245.
Abraham P, Indirani K, Sugumar. E (2007). Decrease in the activities of lysosomal enzymes may contribute to the urotoxicity of cyclophosphamide in the rat. Biomedical Research 18: 20-27. Impact factor of journal: 0.236
Abraham P, Indirani K, Sugumar E (2007). Effect of cyclophosphamide treatment on selected lysosomal enzymes in the kidney of rats. Experimental and Toxicologic Pathology 59(2): 143-9.
Kolli VK, Abraham P, Isaac B (2007). Alteration in antioxidant defense mechanisms in the small intestines of methotrexate treated rat may contribute to its gastrointestinal toxicity. Cancer therapy 5B: 501-510.
Abraham P, Ramakrishna B (2007). Oxidative stress plays a role in the pathogenesis of acetaminophen induced liver damage in the rat. Research and Reviews in Biosciences 1:53-58.
Sivalingam N, Hanumantharaya R, Faith M, Basivireddy J, Balasubramanian KA and Jacob M (2007). Curcumin reduces indomethacin-induced damage in the rat small intestine. Journal of Applied Toxicology 27 (6): 551-560.
Faith M, Eapen CE, Wilfred G, Ramachandran J and Jacob M (2007). Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: a preliminary report. Hepatology Research 37 (1): 13-7.
Jacob M, Foster R, Sigthorsson G, Simpson R and Bjarnason I (2007). Role of bile in pathogenesis of indomethacin-induced enteropathy. Archives of Toxicology 81: 291-8.
Dhanarajan R, Abraham P,and Isaac B (2006). Protective effect of ebselen, a selenoorganic drug , against gentamicin –induced renal damage in rats. Basic and Clinical Pharmacology and Toxicology 99:267.
Vyas R, Satishkumar S, Selvaraj KG, Suganthy J, Faith M, Isaac B and Abraham P (2006). Teaching in basic sciences- a novel approach integrated case-based learning. CMC Alumni Journal 40:11-15.
Natarajan SK, Basivireddy J, Ramachandran A, Thomas S, Ramamoorthy P, Pulimood A, Jacob M and. Balasubramanian KA (2006). Renal damage in carbon-tetrachloride-induced cirrhosis in rats: role of oxygen free radicals. Hepatology 43: 1248-56.
Jacob M and Balasubramaniam N (2006). Excretion of urinary enzymes in normal pregnancy. Clinical Biochemistry 39: 754-757.
Abraham P (2005). Megadose of vitamin C augments the nephrotoxicity of paracetamol. Nephrology 10: 623-625.
Abraham P, Desigamani K and Indirani K (2005). Nitro-arginine methyl ester, a non-selective inhibitor of nitric oxide synthase, reduces ibuprofen-induced gastric mucosal injury in the rat. Digestive Diseases Science 50: 1832.
Abraham P, Indirani K, Bondu JD (2005). Propylthiouracil attenuates acetaminophen induced renal damage in the rat. Nephrology 10: 588-593.
Abraham P (2005). Vitamin C may be beneficial in the prevention of paracetamol induced renal damage. Clinical and Experimental Nephrology 9: 24-30.
Basivireddy J, Jacob M, Ramamoorthy P and Balasubramanian KA (2005). Alterations in the intestinal glycocalyx and bacterial flora in response to oral indomethacin. International Journal of Biochemistry and Cell Biology 37: 2321-2332.
Basivireddy J, Jacob M and Balasubramanian KA (2005). Indomethacin induces free radical-mediated changes in renal brush border membranes. Archives of Toxicology 79: 441-450.
Abraham P (2004). Lysosomal enzyme activity during development of carbon tetrachloride induced cirrhosis in rats. Indian Journal of Physiology and Pharmacology 48: 206-212.
Abraham P (2004). Oxidative stress in paracetamol-induced pathogenesis:(I) renal damage. Indian Journal of Biochemistry and Biophysics 42: 59-62.
Abraham P (2004). Increased protein thiol in the liver and plasma of rats in acute acetaminophen intoxication. Clinica Chimica Acta 339: 203-204.
Abraham P (2004). Increased plasma biotinidase activity in rats with paracetamol induced acute liver injury. Clinica Chimica Acta 349:61-65.
Basivireddy J, Jacob M and Balasubramanian KA (2004). Oral glutamine attenuates indomethacin-induced small intestinal damage. Clinical Science 107: 281-289.
Basivireddy J, Jacob M, Pulimood AB and Balasubramanian KA (2004). Indomethacin induced renal damage: role of oxygen free radicals. Biochemical Pharmacology 67: 587-599.
Selvakumar D and Joseph LBM (2004). Importance of including biomedical ethics in the curriculum of health education institutes. Education for Health 17: 93-96.
Abraham P, Wilfred G (2003). A marked decrease in the activity of biotinidase in the plasma of rats after single dose of carbon tetrachloride. Clinica Chimica Acta 328: 195-97.
Basivireddy J, Jacob M, Ramamoorthy P, Pulimood AB and Balasubramanian KA (2003). Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. Biochemical Pharmacology 65: 683-95.
Abraham P, Wilfred G, Ramakrishna B (2003). Decrease in plasma biotinidase activity with normal albumin concentrations in experimental liver fibrosis. Clinica Chimica Acta 334: 245-247.
Jose JV, Gupta SN and Selvakumar D (2003). Utility of N-terminal pro-brain natriuretic peptide for the diagnosis of heart failure. Indian Heart Journal 55: 35-39.
Abraham P, Wilfred G (2002). A massive increase in serum β-glucuronidase after a single dose of carbon tetrachloride to the rat. Clinica Chimica Acta 322: 183-184.
Basivireddy J, Vasudevan A, Jacob M and Balasubramanian KA (2002). Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochemical Pharmacology 64: 339-349.
Jacob M, Bjarnason I, Simpson RJ (2002). Effects of indomethacin on energy metabolism in jejunal tissue in vivo. Clinical Science 102: 541-546.
Abraham P, Wilfred G (2002). Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat. Clinica Chimica Acta 325: 117-125.
Indrasingh I, Chandi G, Selvakumar D, Jeyaseelan L and Selvakumar V (2002). Histochemical localization and biochemical assay of alkaline phosphatase positive cells in human palatine tonsil. Annals of National Academic Medical Sciences 38: 67-74.
Abraham P, Wilfred G (2001). Oxidative damage to the lipids and proteins of the lungs of rats upon acute exposure to carbon tetrachloride vapours. International Journal of Medical Toxicology and Legal Medicine 3: 22:16-17.
Jacob M, Bjarnason I, Simpson RJ (2001). Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro. Clinical Science 101: 493-498.
Jacob M, Bjarnason I, Rafi S, Wrigglesworth J and Simpson RJ (2001). A study of the effects of indomethacin on liver mitochondria from rats, mice and humans. Alimentary Pharmacology and Therapeutics 15: 1837- 1842.
2000 and earlier
Abraham P, Wilfred G (2000). Lysosomal enzymes in the pathogenesis of carbon tetrachloride induced injury to the kidney and testis in the rat. Indian Journal of Pharmacology 32: 250-251.
Abraham P, Wilfred G, Ramakrishna B (2000). Plasma prolidase may be an index of liver fibrosis in the rat. Clinica Chimica Acta 295: 199-202.
Somasundaram S, Sigthorsson G, Simpson RJ, Watts J, Jacob M, et al (2000). Uncoupling of intestinal mitochondria oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Alimentary Pharmacology and Therapeutics 14: 639-650.
Jacob M. Mechanism of nonsteroidal drug-induced anti-inflammatory drug-induced damage in the small bowel (1999). PhD thesis (University of London).
Abraham P, Wilfred G, Ramakrishna B (1999). Decreased activity of hepatic alkaline protease in rats with carbon tetrachloride-induced liver cirrhosis. Indian Journal of Experimental Biology 37: 1243-1245.
Abraham P, Wilfred G, Cathrine SP (1999). Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication. Clinica Chimica Acta 289: 177-179.
Abraham P, Wilfred G, Ramakrishna B (1999). Effect of administration of the free radical trapping agent “N-tert-Butyl-Alpha-Phenylnitrone” on the prevention of oxidative damage to lipids and proteins of the liver and liver damage in experimental cirrhosis. Journal of Forensic Medicine and Toxicology 16: 26-29.
Jose JV, Selvakumar D, Selvakumar R, Kanagasabapathy AS, Jayaseelan L (1998). Plasma fibrinogen, an independent risk factor for ischemic heart disease. Indian Heart Journal 50: 45-48.
Selvakumar D, Krishnaswami S (1998). Sucrose diet and atherosclerosis. A preliminary report of an experimental study on rat aorta. Indian Heart Journal 50: 65-71.
Mahmud T, Somasundaram S, Sigthorsson G, Simpson RJ, Rafi S, Foster R, Tavares IA, Roseth A, Hutt AJ, Jacob M et al (1998). Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat. Gut 43: 775-782.
Jacob M, Bjarnason I and Simpson RJ (1998). Effects of indomethacin on mitochondrial ATP synthesis. Biochemical Society Transactions 26: S161.
Jacob M, Bjarnason I and Simpson RJ (1998). Effects of indomethacin on mitochondrial oxygen uptake in intestine. Biochemical Society Transactions 26: S162.
Jacob M, Simpson RJ and Bjarnason I (1998). Non-steroidal anti-inflammatory drugs, cyclooxygenase selectivity and gastrointestinal toxicity. Italian Journal of Gastroenterology and Hepatology 30: 12-18.
Jacob M, Bjarnason I and Simpson RJ (1998). In vitro evidence for mitochondrial effects of indomethacin. Biochemical Society Transactions 26: S315.
Sigthorsson G, Jacob M, et al (1998). Comparison of indomethacin and nimesulide, a selective cyclooxygenase inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scandinavian Journal of Gastroenterology 33: 728-735.
Gabe S, Jacob M and Bjarnason I (1998). The intestinal permeability barrier - what is measured, what does it mean? In: Gut and the Liver. Blum HE, Bode CH, Bode JCH, Sartor RB, eds. FDCH Symposium 100. Kluwer Academic Press, Dordre CHT. 31-46.
Sundari PN (Abraham P), Wilfred G, Ramakrishna (1997). Does oxidative protein damage play a role in the pathogenesis of carbon tetrachloride-induced liver injury? Biochimica Biophysica Acta 1362: 169- 76.
Selvakumar D, Selvakumar R, Kanagasabapathy AS, Jayaseelan L (1997). Serum lipoprotein (a) levels in ischemic heart disease. JAPI 45: 10.
Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M et al (1997). Intestinal tolerability of the highly specific COX-2 inhibitor, nimesulide, in the rat. Gut 40: (suppl 1) A71.
Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M et al (1997). Role of uncoupling of oxidative phosphorylation and inhibition of cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gut 40: (suppl 1) A70.
Somasundaram S, Rafi S, Hayllar J, Jacob M, et al (1997). Mitochondrial damage: a possible mechanism of the “topical” phase of NSAID-induced injury to the rat intestine. Gut 41: 344-353.
Somasundaram S, Rafi S, Jacob M, Sigthorsson G et al (1997). Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Gut 40 (5): 608-613.
Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Tavares I, Macpherson A, Bjarnason I (1997). Relative importance of uncoupling of oxidative phosphorylation and inhibition and cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gastroenterology 112 (4S): A290-A290.
Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Mahmud T, Tavares I, Macpherson A, Bjarnason I (1997) Intestinal tolerability of the highly specific-COX-2 inhibitor nimesulide in the rat. Gastroenterology 112 (4S): A291-A291.
Sigthorsson G, Mahmud T, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Tavares I, Macpherson A, Bjarnason I (1997) Role of uncoupling of oxidative phosphorylation and inhibition and cyclooxygenase in the pathogenesis of NSAID-enteropathy in the rat. Gut 40: F280-F280.
Sigthorsson G, Somasundaram S, Roseth A, Foster R, Rafi S, Jacob M, Mahmud T, Tavares I, Macpherson A, Bjarnason I (1997) Intestinal tolerability of the highly specific COX-2 inhibitor nimesulide in the rat. Gut 40: F281-F281.
Jacob M, Wilfred G, Kanagasabapathy AS and Balasubramaniam N (1995). Urinary calcium-creatinine ratio in the prediction of preeclampsia and pregnancy-induced hypertension. Australian and New Zealand Journal of Obstetrics and Gynecology 35: 113.
Jacob M, Wilfred G, Kanagasabapathy AS and Balasubramaniam N (1993). Urinary N-acetyl-b-D-glucosaminidase in the prediction of preeclampsia and pregnancy-induced hypertension. Australian and New Zealand Journal of Obstetrics and Gynecology 33: 395-397.
Wu-Cheng Shen, Selvakumar D, Stanford DR, Hopper AK (1993). The Saccharomyces cerevisiac LOSI gene involved in pre-tRNA splucing encodes a nuclear protein that behaves as a component of the nuclear matrix. Journal of Biological Chemistry 268 (26): 19436-1944.
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Selvakumar D, Wilfred G (1984). Induction of hepatic alkaline phosphatase by methylxanthines: influence of age and sex and the role of adrenals. Indian J Biochem Biophys 21: 191.
Wilfred G, Selvakumar D (1983). Nystatin increases hepatic alkaline phosphatase activity. Biochim Biophys Acta 758: 191-193.
Wilfred G (1979). A possible role of microtubles in the regulation of hepatic alkaline phosphatase. Indian J Biochem. Biophys 16: 90.
Wilfred G, Prakasa Rao J (1977). Effects of in vivo administration of insulin on hepatic alkaline phosphatase. Indian J Experimental Biology 15: 627.
Wilfred G. Colchicine increased hepatic alkaline phosphatase activity (1977). Biochim Biophys Acta 500: 209.
Wilfred G, Prakasa Rao J (1976). Induction of hepatic alkaline phosphatase: phosphodiesterase inhibitors and adrenaline. Indian J Biochemistry 13: 331-334.
Wilfred G, Varma TNS (1974). Studies on biosynthesis of liver lipids in threonine deficient rats. Indian J Biochemistry 11: 237.
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Dumm ME, Rao BRH, Jesudian G and Benjamin V (1967). Indian multipurpose food and supplemented groundnut protein isolate compared as supplements for preschool children. Journal of Nutrition and Dietetics. 4: 285.
Pereira SM, Isaac T, Begum A and Dumm ME (1967). Vitamin A therapy in children with kwashiorkor. American Journal of Clinical Nutrition. 20: 297.
Wilfred G, Varma TNS (1967). Studies on experimental protein malnutrition : Part II. Effect of threonine deficiency on some aspects of glycogen metabolism in rats. Indian J Biochemistry 4: 113.
Wilfred G, Varma TNS (1967). The relationship of mitochondrial function to fatty changes in threonine deficiency. Proc. Soc. Biol. Chem. (India). XXCI: 43.
Varma TNS and Rao RH (1966). Studies on experimental protein malnutrition. Part I. Effect of threonine deficiency on glucose-6-phosphate metabolizing enzymes of rat liver. Indian Journal of Biochemistry. 3: 37.
Dumm ME, Rao BRH, Jesudian G and Benjamin V. (1966). Supplemented groundnut protein isolate for preschool children. Indian Journal of Nutrition and Dietetics 3: 25.
Van Rossum GDV (1966). Simultaneous measurements of Na+24 efflux and pyridine nucleotides in slices of rat liver. Biochimica Biophysica Acta 122: 312.
Dumm ME, Rao BRH, Jesudian G and Benjamin V (1966). Supplemented groundnut protein isolate for preschool children : II. Indian Journal of Nutrition and Dietetics 3: 111.
Pereira SM, Begum A and Dumm ME (1966). Vitamin A deficiency in kwashiorkor. American Journal of Clinical Nutrition 18: 413.
Thomas RI, Pereira SM, Jesudian G and Dumm ME (1965). Serum amino acids of children on high and low protein intakes. American Journal of Clinical Nutrition 17: 11-14.
Rao BRH, Benjamin V, Jesudian G and Dumm ME (1965). Indian multipurpose food and low fat groundnut flour as supplement for school children. Indian Journal of Pediatrics 32: 1-9.
Pereira SM, Thilakavathy I, Tewarson B and Dumm ME (1965). Processed fish protein in the treatment of Kwashiorkor. Indian Journal of Medical Research 53: 651-658.
Van Rossum GDV (1965). Observations on respiratory pigments in slices of avian salt gland and rat liver. II. Evidence for reversal of electrol transfer. Biochimica Biophysica Acta 110: 237.
Van Rossum GDV (1965). Observations on respiratory pigments in slices of avian salt gland and rat liver. I. effects of inhibitors and uncouplers. Biochimica Biophysica Acta 110: 221.
Nassal PM, Hansen IA and Ladd JN (1957). The mechanism of yeast respiration I. Preparation and properties of actively respiring cell free yeast extracts. Biochimica Biophysica Acta 23: 103.
Chapters in books:
Dr. Molly Jacob and Dr. Joe Varghese are co-authors of Harper’s Illustrated Biochemistry, McGraw Hill LANGE, USA (29th to 31st [current] edition).
The chapters contributed to are as follows:
1. David A. Bender, Joe Varghese, Molly Jacob and Robert K. Murray. Chapter 48. Clinical Biochemistry
2. Peter J. Kennelly, Robert K. Murray, Molly Jacob and Joe Varghese. Chapter 52. Plasma Proteins & Immunoglobulins
3. Molly Jacob, Joe Varghese, Robert K. Murray, & P. Anthony Weil. Chapter 56. Cancer: An Overview